منابع مشابه
Chronic calcineurin inhibitor nephrotoxicity: reflections on an evolving paradigm.
Use of the calcineurin inhibitors (CNI) cyclosporine and tacrolimus has revolutionized solid organ transplantation. For more than 30 yr, the transplant community has dealt with nephrotoxicity attributed to these agents. Acute renal vasoconstriction (as described by many investigators, including John Curtis and colleagues) is the unequivocal consequence of their use; chronic CNI nephropathy, alt...
متن کاملCalcineurin inhibitor nephrotoxicity.
The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with excellent short-term outcome. However, the chronic nephrotoxicity of these drugs is the Achilles' heel of current immunosuppressive regimens. In this review, the authors summarize the clinical features and histologic appearance of both acute and chronic calcineurin inhib...
متن کاملMechanisms of Calcineurin Inhibitor Nephrotoxicity in Chronic Allograft Injury
The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between genetically identical twins and therefore immunosuppression was not necessary in this particular case (Merrill et al., 1956). However, solid-organ...
متن کاملThe over-exaggerated chronic nephrotoxicity of calcineurin inhibitors
BACKGROUND Late kidney allograft failure remains a major problem in kidney transplantation. While there is no doubt that acute nephrotoxicity from calcineurin inhibitors (CNIs) exists, chronic CNI nephrotoxicity has been the subject of much debate in the transplant community. METHODS We identified original articles related to the use of CNIs in renal and extra-renal solid-organ transplantatio...
متن کاملPathophysiology and treatment of calcineurin inhibitor nephrotoxicity
and treatment of calcineurin inhibitor nephrotoxicity" (2014). All. Paper 2.
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2011
ISSN: 1600-6135
DOI: 10.1111/j.1600-6143.2011.03505.x